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Reduced appetite for caffeine in adenosine A(2A) receptor knockout mice.

El Yacoubi M, Ledent C, Parmentier M, Costentin J, Vaugeois JM

FRE 2735 CNRS, IFRMP 23, UFR de Médecine and Pharmacie, Rouen Cedex1, France.

Adenosine A(2A) receptor knockout mice (A(2A)R KO) were compared to wild-type controls (A(2A)R WT) in a caffeine intake paradigm. When mice had ad libitum access to caffeine (0.3 g/l) and water in a two-bottle paradigm for 12 consecutive days, adenosine A(2A)R KO mice drank less caffeinated solution, demonstrating a reduced appetite for caffeine as compared to adenosine A(2A)R WT mice. These data reveal an important role for the adenosine A(2A) receptor in the appetitive properties of caffeine.

Published 13 September 2005 in Eur J Pharmacol, 519(3): 290-1.
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